She constantly escapes and is nicknamed "The Escape Artist". Charkie can open doors and simple machines, and enjoys balls and toys. When happy, she flips and has a high-pitched bark. Charkie is mischievous and way out of control.
- She is voiced by Rob Paulsen.
- She never fully learned to be obedient, but George managed to get her to graduate Obedience school. (Charkie Goes to School)
- She once sprained The Man with the Yellow Hat's ankle when she jumped in front of him while he was running. (Curious George, Personal Trainer)